Formulation and evaluation of gastro retentive drug delivery system of candesartan cilexetil
نویسندگان
چکیده
It had became a challenging experience and effort for formulator to develop innovate drug with maximum bioavailability. In the present study focus of research is in treatment Hypertension, which one most prevalent cardiovascular diseases world, affecting big proportion adult old age population. Candesartan Cilexetil angiotensin II AT1 many tissues including vascular smooth muscle adrenal glands, used high blood pressure. The has poor bioavailability due limited oral absorption at proximal intestine. This warrants offers use Gastro Retentive Drug Delivery System (GRDDS) sustained release formulation order achieve prolonged action improve patients compliance. Wet granulation technique was selected preparation tablets formulated HPMC K100M, ethylcellulose, sodium bicarbonate, Micro crystalline cellulose, Gelucire, talc Aerosil etc. For around twelve formulations were made evaluated General appearance, Thickness, Hardness or Crushing strength Test, Friability Estimation content, In-vitro buoyancy studies results obtained performed tests found range specified limits.
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ژورنال
عنوان ژورنال: International Journal of Health Sciences (IJHS)
سال: 2022
ISSN: ['2550-6978', '2550-696X']
DOI: https://doi.org/10.53730/ijhs.v6ns1.6150